Description
GPR115 is a member of the LN-7TM family of adhesion-type7-transmembrane (TM) G-protein coupled receptors (GPCR) that show a longextracellular N-terminus. The 695 amino acid (aa) human GPR115 sequencepredicts a 21 aa signal sequence, a 385 aa N-terminal extracellular domain(ECD), seven TM regions separated by 6-24 aa intracellular and extracellularregions, and a 40 aa cytoplasmic tail. Like other LN-7TM members, the ECDcontains a highly glycosylated mucin-like stalk that is predicted to functionin adhesion. This is followed by a cysteine-rich GPCR proteolytic cleavagesite (GPS)